Universalization or localization? Issues of knowledge legitimation in comaprative education

The endeavor to unite the universal and the accidental in both, the physical and the social world into one theoretical framework – the idea of such a unity can be found already in the Chinese concept of Tao – dates back in the modern culture to the Enlightenment. Such a unified knowledge came to be understood as a potential tool of forecasting and controlling societal progress. All through the positivistic 19th century, comparativists followed Marc-Antoine Jullien de Paris, who thought educational comparison should become an exact science whose outcomes could be used anywhere and transplanted to any place. It was Michael Sadler who as the first comparative educationalist strictly refused the idea of cultural and institutional borrowing. Under his influence comparative education focused on the variations unique to the single countries and to the factors underlying these variations. Even the later emerging functionalist method remained in the tradition of a „one-dimensional logic“, which, as Marcuse alleged, was inseparably connected with the rationale of domination of nature and society. It is only the postmodern sight, which – without giving up the humanistic ideas of modernity which originated in Western modernization – opens possibilities to enter a cross cultural dialogue and to accept multiple theoretical realities. (DIPF/Orig.)Der Beitrag bietet einen breiten Überblick über grundlegende Tendenzen in der historischen Entwicklung von Vergleichender Erziehungswissenschaft. Dabei unterliegt der Darstellung implizit und explizit durchgängig das Bewußtsein, daß vergleichende Wissenschaft im weitesten Sinne weder ein Monopol der jüngsten Epoche noch etwa eines einzigen Kulturraums darstellt. Mit seiner analytischen, aber auch normativen Interpretation von gegenwärtigen Tendenzen postmodernen Denkens sieht er die Möglichkeit eines transkulturellen Dialogs über die Weiterentwicklung und Erweiterung der etablierten (westlichen) Vergleichenden (Erziehungs-)Wissenschaft. (DIPF/Orig.

Automated silicon debug data analysis techniques for a hardware data acquisition environment

Abstract—Silicon debug poses a unique challenge to the en-gineer because of the limited access to internal signals of the chip. Embedded hardware such as trace buffers helps overcome this challenge by acquiring data in real time. However, trace buffers only provide access to a limited subset of pre-selected signals. In order to effectively debug, it is essential to configure the trace-buffer to trace the relevant signals selected from the pre-defined set. This can be a labor-intensive and time-consuming process. This paper introduces a set of techniques to automate the configuring process for trace buffer-based hardware. First, the proposed approach utilizes UNSAT cores to identify signals that can provide valuable information for localizing the error. Next, it finds alternatives for signals not part of the traceable set so that it can imply the corresponding values. Integrating the proposed techniques with a debugging methodology, experiments show that the methodology can reduce 30 % of potential suspects with as low as 8 % of registers traced, demonstrating the effectiveness of the proposed procedures. Index Terms—Silicon debug, post-silicon diagnosis, data acqui-sition setup I

Piver Type II vs. Type III Hysterectomy in the Treatment of Early-Stage Cervical Cancer: Midterm Follow-up Results of a Randomized Controlled Trial

Introduction: With the expansion of value-based medicine, we explore whether using type III hysterectomy to treat low-risk, early-stage cervical cancer constitutes overtreatment. In present study, we evaluate the midterm safety and postoperative quality of life of patients who underwent type II hysterectomy vs. type III hysterectomy with systematic lymphadenectomy for low-risk early-stage cervical cancer (International Federation of Gynecology and Obstetrics (FIGO) IA2-IB1; maximum tumor diameter < 2 cm).Patients and methods: The main study was a multicenter, phase III, randomized controlled trial (NCT02368574, https://www.clinicaltrials.gov/ct2/show/NCT02368574). Patients meeting the criteria were randomly divided into type II and type III hysterectomy groups between 2015 and 2018. Midterm outcomes were analyzed at 36 months after the first eligible patient was enrolled. The primary end point was disease-free survival, and the secondary end point was postoperative quality of life.Results: A total of 97 patients were preliminarily enrolled, 93 of whom were included in the final analysis. The general information of the two groups did not differ. The 2-year DFS rate in the type II group was 100% compared with 97.9% in the type III group (P > 0.05). Compared to the type III group, the patients who underwent type II hysterectomy showed a shorter surgical time (163 ± 18.8 min vs. 226 ± 16.4 min, P = 0.014), less intraoperative blood loss (174 ± 27.7 ml vs. 268 ± 37.4 ml, P = 0.047), less postoperative urinary retention (5/46 vs. 11/47 cases, P = 0.109), and milder bladder injuries. The postoperative symptom experience scores of the type II group were significantly lower than those of the type III group. Moreover, the postoperative sexual/vaginal functioning and lubrication scores of the type II group were significantly lower than those of the type III group in subgroup analyses of patients who did not undergo postoperative chemoradiotherapy. Sexual apprehension scores were increased postoperatively in both groups.Conclusion: Based on the midterm analysis, the two groups show considerable security within 2 years after surgery, but long-term security requires further analysis. Type II hysterectomy can effectively reduce the surgical time and intraoperative blood loss, decrease postoperative complications, and improve the quality of life of early-stage cervical cancer patients

Genomic Comparison of Endometrioid Endometrial Carcinoma and Its Precancerous Lesions in Chinese Patients by High-Depth Next Generation Sequencing

Endometrial intraepithelial neoplasia (EIN), also known as endometrial atypical hyperplasia (EAH) is believed to be the precursor lesion of endometrioid endometrial carcinoma (EEC). Many genetic factors play important roles in the process of carcinogenesis, however, the key genetic alterations from dysplasia to endometrial cancer remains poorly understood. Germline mutations in Lynch syndrome genes are associated with hereditary endometrial carcinoma. The role of other cancer susceptibility genes is unclear. The aim of this study was to investigate the genomic alterations of premalignant endometrial lesion and EEC, and to determine the prevalence of cancer predisposition gene mutations in an unselected endometrial carcinoma patient cohort. Here, we applied a comprehensive cancer gene panel (363 cancer-related genes) to capture the exomes of cancer-related genes. Samples were collected from 79 patients with EEC and 36 patients with EIN. Our results demonstrate that EIN harbors most of the driver events reported in EEC and for the first time we reported a high frequency of the amplification of VEGFB gene in endometrial cancer. Moreover, we identified four novel candidate cancer-associated genes (CTCF, ARHGAP35, NF1, and KDR) which may be crucial in the carcinogenesis of EEC. In addition, we identified 2 patients who had a deleterious germline mutation in Lynch syndrome genes (MLH1 and MLH2), and another 8 patients harbored germline mutations of 6 non-Lynch syndrome genes (MUTYH, GALNT12, POLE, MPL, ATM, and ERCC4) which may be associated with endometrial cancer. Larger series will have to be investigated to assess the risks and the proportion of endometrial cancers attributable to other genes

GRIM-19 Disrupts E6/E6AP Complex to Rescue p53 and Induce Apoptosis in Cervical Cancers

BACKGROUND: Our previous studies showed a down-regulation of GRIM-19 in primary human cervical cancers, and restoration of GRIM-19 induced tumor regression. The induction of tumor suppressor protein p53 ubiquitination and degradation by E6 oncoportein of high risk-HPV through forming a stable complex with E6AP is considered as a critical mechanism for cervical tumor development. The aims of this study were to determine the potential role of GRIM-19 in rescuing p53 protein and inducing cervical cancer cell apoptosis. METHODOLOGY/PRINCIPAL FINDINGS: The protein levels of GRIM-19 and p53 were detected in normal cervical tissues from 45 patients who underwent hysterectomy for reasons other than neoplasias of either the cervix or endometrium, and cervical cancer tissues from 60 patients with non-metastatic squamous epithelial carcinomas. Coimmunoprecipitation and GST pull-down assay were performed to examine the interaction of GRIM-19 with 18E6 and E6AP in vivo and in vitro respectively. The competition of 18E6 with E6AP in binding GRIM-19 by performing competition pull-down assays was designed to examine the disruption of E6/E6AP complex by GRIM-19. The augment of E6AP ubiquitination by GRIM-19 was detected in vivo and in vitro ubiquitination assay. The effects of GRIM-19-dependent p53 accumulation on cell proliferation, cell cycle, apoptosis were explored by MTT, flow cytometry and transmission electron microscopy respectively. The tumor suppression was detected by xenograft mouse model. CONCLUSION/SIGNIFICANCE: The levels of GRIM-19 and p53 were concurrently down regulated in cervical cancers. The restoration of GRIM-19 can induce ubiquitination and degradation of E6AP, and disrupt the E6/E6AP complex through the interaction of N-terminus of GRIM-19 with both E6 and E6AP, which protected p53 from degradation and promoted cell apoptosis. Tumor xenograft studies also revealed the suppression of p53 degradation in presence of GRIM-19. These data suggest that GRIM-19 can block E6/E6AP complex; and synergistically suppress cervical tumor growth with p53